L-Ornithine-L-Aspartate

L-Ornithine-L-Aspartate Infusion Injection
5 gm/10 ml
 
Description:
L-Ornithine-L-Aspartate is a combination amino acids.
Chemically,L-Ornithine-L-Aspartate is (S)-2,5-Diaminopentanoic acid L-Aspartate salt. The molecular formula is C₉H₁₉N₃O₆ and molecular weight is 265.27.
Actions: 
It is well known that both ornithine and aspartic acid play a key role in the liver metabolism. In fact, ornithine is the starting point of which ammonia is converted into urea, a non-toxic substance. The other component of the drug, aspartic acid, not only represents as important stage in the reaction sequence involved in the urea cycle, but also features in the tricarboxylic acid cycle as oxaloacetate formed by transamination, thereby improving the energy balance of the diseased liver. Furthermore, aspartic acids promote natural regeneration of the liver cells by taking part in pyrimidine biosynthesis.
Indications: 
For the treatment of hyperammonemia as a result of acute and chronic liver diseases such as liver cirrhosis, fatty liver, hepatitis; especially for the treatment of incipient disturbances of consciousness (pre-coma) or neurological complications (hepatic encephalopathy). As ornithine aspartate exerts its action in the metabolic cycles of the liver, elevated blood ammonia levels are rapidly lowered. The capacity of detoxification, particularly of the urea cycle, is enhanced.
 
Dosage:
a. On the first day : Depending on severity of the condition between 8 to 20 ampoules in divided doses. Satisfactory results were obtained when 8 ampoules were used in the first  quarter of the day followed  by 4 ampoules in each of next three quarters.
b. From 2nd day onwards : 8 ampoules per day. The duration of administration is dependent on the course of the disease.
Storage:
Store below 30°C (86°F), protected from light.
Do not refrigerate.